Fragility and volatility of structural hubs in the human connectome

LL Gollo; JA Roberts; VL Cropley; MA Di Biase; C Pantelis; A Zalesky; M Breakspear

Journal article

Fragility and volatility of structural hubs in the human connectome

LL Gollo, JA Roberts, VL Cropley, MA Di Biase, C Pantelis, A Zalesky, M Breakspear

Nature Neuroscience | NATURE PORTFOLIO | Published : 2018

DOI: 10.1038/s41593-018-0188-z

Abstract

Brain structure reflects the influence of evolutionary processes that pit the costs of its anatomical wiring against the computational advantages conferred by its complexity. We show that cost-neutral ‘mutations’ of the human connectome almost inevitably degrade its complexity and disconnect high-strength connections to prefrontal network hubs. Conversely, restoring the peripheral location and strong connectivity of empirically observed hubs confers a wiring cost that the brain appears to minimize. Progressive cost-neutral randomization yields daughter networks that differ substantially from one another and results in a topologically unstable phenomenon consistent with a phase transition in ..

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University of Melbourne Researchers

Vanessa Cropley Author

Maria Di Biase Author

Christos Pantelis Author

Andrew Zalesky Author

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Grants

Awarded by Sylvia and Charles Viertel Charitable Foundation

Funding Acknowledgements

The authors thank the chief investigators and manager of the ASRB: V. Carr, U. Schall, R. Scott, A. Jablensky, B. Mowry, P. Michie, S. Catts, F. Henskens, and C. Loughland. The authors acknowledge the support of the National Health and Medical Research Council of Australia (APP1110975 to L.L.G.; APP1145168 and APP1144936 to J.R.; APP1037196, APP1118153, and APP1095227 to M.B.; APP1047648 to A.Z.; and ID1105825 to C.P.) and the Australian Research Council (CE140100007). The Australian Schizophrenia Research Bank (ASRB) is supported by the NHMRC (enabling grant 386500), the Pratt Foundation, Ramsay Health Care, the Viertel Charitable Foundation, and the Schizophrenia Research Institute.